9.05 Smart magnetic systems based on biohybrid nanocomposites (SMSBN)

Research

This project will establish a novel class of smart biohybrid structures and devices based on magnetic nanoparticles and self-assembled supramolecular structures composed of DNA.The developments made within the project will lay the foundation for novel magneticmetamaterials with numerous potential applications ranging from fundamental physical studies over (bio)sensing to reconfigurable hardware and nanorobotics. On a fundamental level, we will gain more understanding of the local behaviour and interactions of magnetic dipoles by the precise control of their nanoscopic geometry and distances. These fundamental insights will then be used to direct the assembly of magnetic nanoparticles into large-scale ordered lattices and crystals, resulting in "meta-ferromagnetism" or relatedphenomena. Integration of magnetic nanoaparticles into DNA-based molecular devices will result in smart, switchable, magnetic coatings and sensors. On the long run, magnetic biohybrid structures may be utilized as components of nanorobotic and reconfigurable molecular systems.

Publications

Kopperger, E. et al. (2018) A self-essembled nanoscale robotic arm controlled by electric fields", Science, 359, 296-301. doi: 0.1126/science.aao4284

Joos, A., Löwa, N., Wiekhorst, F., Gleich, B., & Haase, A. (2017). Size-dependent MR relaxivities of magnetic nanoparticles. Journal of Magnetism and Magnetic Materials, 427, 122-126. doi: 10.1016/j.jmmm.2016.11.021

Sagredo, S., Pirzer, T., Aghebat Rafat, A., Götzfried, M. A., Moncalian, G., Simmel, F. C., & de la Cruz, F. (2016). Orthogonal Protein Assembly on DNA Nanostructures Using Relaxases. Angewandte Chemie International Edition. doi: 10.1002/anie.201510313

Joos, A., Rümenapp, C., Wagner, F. E., & Gleich, B. (2016). Characterisation of iron oxide nanoparticles by Mössbauer spectroscopy at ambient temperature. Journal of Magnetism and Magnetic Materials, 399, 123-129. doi: 10.1016/j.jmmm.2015.09.060

Kopperger, E., Pirzer, T., Simmel, F. C. (2015) Diffusive transport of molecular cargo tethered to a DNA origami platform, Nano letters, 15(4), 2693-2699. doi: 10.1021/acs.nanolett.5b00351

Team

Project team leader

Dr. Tobias Pirzer
Chair of Physics of Synthetic Biological Systems (E14)

Alumnus

Dr. rer. nat. Ali Aghebat Rafat
Chair of Physics of Synthetic Biological Systems (E14)

Alumna

Dr. rer. nat. Marisa Götzfried
Chair of Biomedical Physics

Alumnus

Dr. rer. nat. Enzo Kopperger
Chair of Physics of Synthetic Biological Systems (E14)

Alumnus

Dr. rer. nat. Alexander Joos
Chair of Biomedical Physics

Principal investigator

Professor Friedrich Simmel
Chair of Physics of Synthetic Biological Systems (E14)

Principal investigator

Dr.-Ing. Bernhard Gleich
Chair of Biomedical Physics