The project teams E-Cas and cellMATh welcome applications for 2 PhD positions.

1PhD position in project team 13.08 E-Cas

PhD position (scholarship) in Biocatalysis & Enzyme Engineering Project

The PhD project in project team E-Cas deals with the production of fuels and chemicals by a synthetic enzymatic cascade reaction. Four doctoral candidates from TUM and the University of Queensland (UQ) in Australia will cooperate to optimize four enzymes of a previously designed cascade reaction required to convert glucose to isobutanol. To achieve this goal, we will be using structural and mechanistic insight in combination with bioinformatics tools (molecular design and sequence reconstruction) and experimental approaches (high throughput techniques and robotics) to rationally and semi-rationally design enzymes that have increased catalytic activity and stability. Optimized enzymes will then be used to reconstitute the cascade and to design an optimal reaction setup to maximize productivity and yield. The outcome will provide a blueprint for the cell-free enzymatic conversion of renewable raw material into value-added chemicals.

Your profile

  • Excellent Master´s degree (or equivalent) in biochemistry, chemistry, biotechnology, biology or related disciplines.
  • Applicants with strong background in molecular biology and protein biochemistry are preferred.
  • Highly motivated and keen on working in an international and interdisciplinary team.

 We offer

  • A stipend of €2000 per month for 36 months
  • Membership in the International Graduate School of Science and Engineering (IGSSE).
  • Extra funding for international travel (including a research stay of 3 month at the University of Queensland in Brisbane)

TUM is an equal opportunity employer. Qualified women are therefore particularly encouraged to apply. Applicants with disabilities are treated with preference given comparable qualification.
Envisaged start of the project is the 1st of February 2019.

Please send your application materials, including a cover letter, a CV, your degree including a detailed transcript of records, and contact information of two referees to bew_cbr@cs.tum.de or Technische Universität München | Prof. Dr. Volker Sieber | Lehrstuhl für Chemie Biogener Rohstoffe | Schulgasse 16, 94315 Straubing | www.rohstoffwandel.de

1 PhD position in project team 13.04 cellMATh

The Chair of Mathematical Modelling, group Mathematics in Life Sciences, at the Technical University of Munich (Prof. Dr. Christina Kuttler) is looking for a PhD candidate to work on the project cellMATh: Quantifying Effects of Extracellular Matrix Mechanical Properties on Tumor Growth, in collaboration with the Chair of Numerical Analysis of the Technical University of Munich and the Institute of Computational Engineering and Sciences (ICES) at UT Austin.

The ideal PhD candidate should have background in mathematical modeling, and/or numerical analysis and uncertainty quantification. Ability and willingness to work and collaborate in an interdisciplinary research team is essential. The candidate is expected to apply and develop Bayesian inversion techniques for parameter estimation in mathematical models for tumor growth, as well as to participate in the development of these models.

The PhD program requires a research stay of at least 3 months at the ICES institute of UT Austin. No teaching duties are required.
Interested candidates with a Diploma / Master degree in Mathematics or a related field are invited to send curriculum vitae, transcript of records and two contacts for recommendation letters to Prof. Dr. Christina Kuttler. Applications will be considered until the position is filled. For further information contact Prof. Kuttler.